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Between 1537 and 1559, books published in Europe and Mexico commonly referred to the medicinal uses of tobacco among the indigenous populations of the New World, with eyewitness accounts of its therapeutic application in general bodily ills, catarrh, colds, and fevers, as an aid to digestion and in prevention of hunger and thirst, as a purgative and as a narcotic

Cultivation of tobacco was labor intensive, and the colonists used indentured laborers from England and slaves kidnapped from Africa as their workforce

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They restrict airflow

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Data on the percentage of cigarette butts within total anthropogenic litter were available in 1,929 records (70.9%) from 91 articles across 50 countries (Table S3)