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Therefore, lung-derived cytokines may well be the prime explanation of the higher TNF-, IL-2, IL-4, IL-6 and IL-10 concentrations and the lower level of the anti-inflammatory IL-12p70 concentration in smokers than non-smokers, indicating that even young-adult asymptomatic smokers suffer from a low-grade systemic inflammation
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doi:10.1016/j.atmosenv.2013.08.026
