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Scandinavian Tobacco Group

PMID 6961509

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60 Nicotine in its pure form is a clear, oily liquid, alkaline in nature

Conditional recommendation for the intervention, low certainty Recommendation 12 For people who are attempting to quit smoking using varenicline accompanied by behavioural support, clinicians might recommend the use of varenicline in combination with nicotine replacement therapy, compared with varenicline alone

[11] [63] When nicotine enters the brain it stimulates, among other activities, the midbrain dopaminergic neurons situated in the ventral tegmental area and pars compacta