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In particular, it is reported that cEDS patients may show delayed motor development with mild hypotonia, characteristic facial features, fatigue and muscle cramps, premature rupture of fetal membranes, cervical insufficiency during pregnancy, rectal prolapse in early childhood, mild scoliosis, and cardiac/blood vessel fragility including mitral/tricuspid valve prolapse, and aortic root dilatation

They have found that the brain adjusts to prolonged exposure to nicotine by turning down the volume in two ways: 1

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