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In an investor call on Wednesday, Chief Scientific and Product Officer Dan Skovronsky said this outcome sheds further light on how incretins may have a positive effect on other diseases independent from weight loss. Lilly is also testing tirzepatide with the interleukin blocker Omvoh in Phase 3b trials of Crohns disease and ulcerative colitis, Skovronsky added.

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Possible decreased effectiveness of hormonal birth control Tirzepatide (Mounjaro and Zepbound) was shown in clinical trials to reduce birth control pill blood levels by 20-60% when given as an initial single dose

The largest study to date is a 2024 study with 50,000 pregnant people with type 2 diabetes

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Ending this project was bittersweet, because it was my last collaboration with him. He was always asking, How do we help people the fastest? Using a drug thats already shown to be safe to help people reduce drinking could be a way to get people help fast, DiFeliceantonio said