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Using the same spot repeatedly can cause skin changes and affect absorption

However, due to the nausea often associated with these drugs, initiating treatment at a lower dose and gradually increasing it can improve tolerability

3).These data suggest that P5 has superior antihyperglycaemic efficacy in diabetic ob/ob mice

Delayed gastric emptying causes the stomach to remain filled with acidic contents for a longer period, increasing the risk that these will flow back into the esophagus and thereby worsen heartburn, acid regurgitation, or chest pain

Available from: Hampl SE, Hassink SG, Skinner AC, Armstrong SC, Barlow SE, Bolling CF et al