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Activation of these cells leads to the secretion of inflammatory cytokines such as (IL-1, IL1, IL-2, IL-6, IL-8, IL-12, IL-17, IL-23, TNF- and IFN)

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In particular, large cohort studies indicate that e-cigarette use and snus use are not associated with lower rates of COVID-19 diagnosis ( While mechanistic exclusion of nicotine is not possible on current evidence, current data provide limited support for nicotine alone being sufficient to induce a sustained epithelial antiviral state capable of reducing early susceptibility to infection

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