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doi: 10.1371/journal.pmed.1001611

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It warned about serious side effects including: depression, suicidal ideation, suicide attempt, and completed suicide. The black box has been removed, but the warning remains: neuropsychiatric adverse events have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation, suicide attempt and completed suicide. Does Chantix Cause Depression