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The pathogenesis includes nicotine/acetylcholine-incited follicular occlusion, immune dysregulation, and follicular rupture
How well this works depends on carbon amount, airflow, moisture, and how quickly the carbon becomes saturated

The Lausanne researchers also compared the relative amounts of toxic emissions from the IQOS with a Lucky Strike Blue Light cigarette

Health Canada, Smoking and Chronic Obstructive Pulmonary Disease, September 22, 2011

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It is all too easy to allow emotion and preconceived beliefs to overshadow evidence, to retreat into long-established camps rather than join forces in common cause