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Various mechanisms have been proposed for heavy smokers in response to resistance to IFN therapy [59]: The immunosuppression due to heavy smoking results in the depletion of CD4+ cells, impairment in the cytotoxic activity of NK cells, and identification of virus-contaminated cells, and induction of lymphocyte apoptosis Chain smoking raises the level of iron in the hepatic organ, which provides resistance to IFN

A larger SBS score means the subject is closer to the SZ than to the BP end of the psychotic spectrum