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Theres no definitive answer for whether or not metformin or spironolactone are better for PCOS because they treat slightly different symptoms

The body must readjust and return to functioning naturally without nicotine

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For people with HIV in particular, smoking may exacerbate the risk of infections associated with weakened immune systems, such as Pneumocystis pneumonia, according to the US Centers for Disease Control and Prevention, and there may be an increased risk of smoking-related diseases