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For instance, the Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein induces humoral immunity in animal models as well as in non-human primates (Diego-Martin et al., 2020

A significant turning point, however, came in 1614 when John Rolfe (the man who went down in history as marrying the native chiefs daughter Pocahontas) finally succeeded to cultivate a strain of the tobacco plant in Virginia which he had managed to smuggle out of the West Indies