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The p53 knock-in and knockout mouse model models mimic initiating events in human tumorigenesis and progression, which are essential for preclinical studies [60]

These aren't ordinary lozenges

In fact, p53 accumulation (due to increased half-life of the protein) was detected in UVR-exposed skin cells, where p53 plays an active function as a transcriptional regulator [11]

2019) Oreskes, Naomi, and Erik M

Mechanically, p53 induced by DNA damage activates p21

The Bottom Line: Nicotine leads to addiction, and addiction leads to a brain disease. Putting aside the controversy of whether vaping is a win or loss for public health, I think we can all agree that nicotine (the psychoactive addictive chemical found in e-cigarettes and tobacco smoke) inevitably leads to addiction, and that addiction is a brain disease