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cigarette smoke induces cytoplasmic p53 accumulation smoke-induced toxicity consequences of intracellular iron dysregulation and ferroptosis The mutagenic effect of tobacco
Description
Proteomics Bioinformatics 7 (4), 147154
Pham PT, Fukuda D, Nishimoto S, Kim-Kaneyama JR, Lei XF, Takahashi Y, et al
In mouse models of pancreatic and lung cancer, loss of p53 regulates the tumor microenvironment, which promotes the accumulation of suppressor Treg cells as well as impairs Th1 and CD8 + T cell responses [62]
Reactive oxygen species induced p53 activation: DNA damage, redox signaling, or both
This process results in formation of two major metabolites: a non-toxic 3-hydroxy-APAP and a highly reactive metabolite N-acetyl-p-benzoquinone-imine (NAPQI) (Hazai et al., 2002)
doi: 10.3390/ijms140815260
