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Nature, 542 (7640), 177185

For the primary composite outcome and secondary hierarchical outcomes, the threshold for two-sided statistical significance was set to 0.0322 (one-sided level 0.00161) using Lan-DeMets alpha spending function, which allows to adjust significance levels as data were reviewed for the interim analysis, reducing the chance of false positive results

The plan definitely works if you follow it

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While some claims based on prior diagnoses may be excluded, the decision enables the MDL to move forward efficiently

Brenner emphasizes that tinnitus doesnt just affect the ears it impacts the brain and emotional well-being