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Initially introduced as a harm-reduction tool, e-cigarettes have increasingly become a popular alternative to traditional smoking

Within certain functional medicine and CIRS protocols, nicotine has been explored as a supportive adjunct

Clin Chim Acta 431:185191 Soumaoro LT, Iida S, Uetake H, Ishiguro M, Takagi Y, Higuchi T, Yasuno M, Enomoto M, Sugihara K (2006) Expression of 5-lipoxygenase in human colorectal cancer

But, what can be more classic than a pipe from 1919

Mixing more air with the smoke by designing a better ventilated cigarette can reduce nicotine intake by diluting the smoke

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