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The heterogeneity in these results is likely multifactorial, arising from variations in study design, population characteristics, and adjustments for key confounders such as BMI and socioeconomic status (SES) 9,10

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Statistical Testing and LOQ/LOD Results Statistical analysis of the data from all the studies was performed using Minitab version 16 (Minitab Inc, PA, United States) and Minitab version 20

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Notable market shares: Capsules are perceived as smoother, lighter, and less harmfulattributes engineered to attract younger audiences and differentiate brands

The move has catapulted Spain to the forefront of countries seeking to crack down on what the UN describes as the most discarded waste item worldwide: the estimated 4.5tn cigarette butts littered each year