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Keywords: tobacco, immunity, inflammation, autoimmunity, cigarette smoke, nicotine Introduction More than 400,000 people die each year in the United States alone as a result of past or current cigarette smoke (CS) use

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These shifts reinforced chronic inflammation and oncogenic signaling, linking smoke-related dysbiosis to colorectal tumorigenesis [106]

To help keep him on track, Bale said he would regularly sit around wearing headphones but not actually listen to anything so he could hear what was going on around him without being distracted