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Mazdutide vs Retatrutide The Triple vs Dual Receptor Question Retatrutide takes the multi-receptor approach further by adding glucagon receptor activity to Tirzepatides GLP-1/GIP dual agonism making it a GLP-1/GIP/glucagon triple receptor agonist

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Nauck MA, Quast DR, Wefers J, Pfeiffer AFH

Since tirzepatide typically produces greater weight loss (20-25% body weight versus 15-17% with semaglutide at weight loss doses), more tirzepatide users may experience telogen effluvium simply because they lost more weight faster

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Core temperature should be closely monitored because hyperthermia may recrudesce after paralysis is lifted