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Mendelian randomisation (MR) analysis In the present study, a modified Mendelian randomisation approach was performed to investigate a potential causal relationship 36,65 , in which non-pleiotropic polygenic risk scores (i.e., the valid-PRS) were established as instrument variables of randomised experiments for potential causal inference

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The proportion of students who could afford the equivalent of a pack of cigarettes increased from 1996 to 2005, then remained generally steady until 2011