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We recently linked hyperactivation of Nrf2 through both mutational and transcriptional mechanisms to acquisition and maintenance of resistance to chemotherapy and radiation, the two mainstay treatments for HNSCC as well as for many other solid tumors [18, 19, 51]

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Hence, it is critical to determine the role of p53 status in radiotherapy (Fig

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In seminal findings by Rudin et al., SCLC subtypes were defined by the expression of four transcription factors: achaete-scute homologue 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3) [128]

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