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15,16 When nicotine exposure was combined with hormonal (cholecystokinin) stimulation in rats, decreased enzyme secretion and retention of zymogens within pancreatic acinar cells was observed

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Sanchez ES, Bigbee JW, Fobbs W, Robinson SE, Sato-Bigbee C (2008)

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While this process probably yields fair results, we feel that its a little too rustic and doesnt anticipate any issues