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One of the ways in which you can determine whether an individual is a smoker or has been exposed to significant environmental amounts of tobacco smoke over a long period of time is to use what researchers call "biomarkers"

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Methods and Materials Subjects This cross-sectional study included 68 chronic cigarette smoking individuals, hereafter referred to as smokers (35 males, age: 35.3 12.6 (mean standard deviation (s.d.)), age ranged from 19 to 58), and 66 individuals who have smoked less than 10 cigarettes throughout their lifetime, hereafter referred to as controls (33 males, age 33.0 8.2 (mean s.d.), age ranged from 21 to 51)

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