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Diffuse pharmacophoric domains of vasoactive intestinal peptide (VIP) and further insights into the interaction of VIP with the N-terminal ectodomain of human VPAC1 receptor by photoaffinity labeling with [Bpa6]-VIP
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Recent studies using three-dimensional (3-D) electron microscopy and confocal imaging have demonstrated an intimate synaptic relationship between enteroendocrine cells and nerves and glia (282, 406, 407, 418), providing an anatomical substrate for activation of enteric and extrinsic reflexes, and glial signaling (FIGURE 9)
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