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In that sense, our study, despite its methodological weaknesses mentioned above, is original and provides valuable insights

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Interestingly, Arredondo et al

The USPS Ruling on Vaping Products Following the PACT Act amendment, the United States Postal Service (USPS) issued a final ruling in 2021 that effectively prohibited the mailing of most vaping products through the domestic mail system

Nicotine Replacement Therapy (NRT): Nicotine, the addictive component in cigarettes, is also found in e-cigarettes, making vaping an effective form of nicotine replacement therapy (NRT)

Since then, several studies have proven the critical role of nAChRs activation in modulating neuro-immune pathways, and nicotine has been investigated as an effective therapeutic in neurodegeneration and neuroinflammatory diseases [193, 194]