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Cigarette smoke affects digestion through multiple mechanisms: Nicotine stimulates the parasympathetic nervous system Inhaled chemicals create an inflammatory response in the gut Carbon monoxide alters blood flow to digestive organs Smoke exposure changes gut microbiome composition Research shows smoking encourages development of certain bowel diseases while potentially deterring others

10 , CD006611 (2019)

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Tyrosinase drives the complex conversion of tyrosine to melanin

doi: 10.1378/chest.13-0873