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lack of MC ligands): while individuals carrying a mutation in this gene present with fair skin and red hair (202), Pomc - / - mice on a black coat mouse strain (129;B6) are still black, due to the high ligand independent activity of this receptor (203)

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Map kinase links the transcription factor microphthalmia to C-kit signalling in melanocytes

In addition, MC4R signaling in the parabrachial nucleus of the brainstem has been implicated in the suppression of odor-guided food-seeking behavior (Shionoya et al., 2023)

[DOI] [PubMed] [Google Scholar] 397.Souftas V., Deuteraiou D., Anthoulaki X., Chalkidou A., Bothou A., Gaidatzi F., Tsypsianis G., Iatrakis G., Zervoudis S., Souftas D., et al

This stress damages brain cells by disrupting their structure and function