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In seminal findings by Rudin et al., SCLC subtypes were defined by the expression of four transcription factors: achaete-scute homologue 1 (ASCL1), neurogenic differentiation factor 1 (NEUROD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3) [128]

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a low ATP/ADP ratio) activates AMPK, which in turn promotes catabolism and inhibits anabolism [72, 74]

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