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Methods Design This study primarily adapted the research design and protocol of the Tobacco Pack Surveillance System (TPackSS) and its 2015 Field Collection Protocol developed by the Institute for Global Tobacco Control (IGTC) at the Johns Hopkins Bloomberg School of Public Health [36]

Liquid Formulation Safety Liquid safety is entirely separate from device safety and covers two distinct concerns

Decreased tobacco-specific nitrosamines by microbial treatment with bacillus amyloliquefaciens DA9 during the air-curing process of burley tobacco