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Except the first meaning, the latter two are very well valid and both applicable to nicotine and caffeine

Health authorities here are actively courting the vape industry in an effort to cut smoking rates, thereby contributing to the rise in vaping

while also not existing in it at all

A meta-analysis of Mendelian randomization (MR) studies assessing the causal association of smoking in a variety of diseases and a two-sample MR study of risk factors for epilepsy identified that genetic liability to smoking was associated with increased risk of epilepsy (11, 12)

the recall rate has marginally improved from 0.989 to 0.991, a 0.2% increment