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[PubMed: 15248844] Anzengruber D, Klump KL, Thorton L, Brandt H, Craw-ford S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, LaVia M

NEUROCHEMICAL DIFFERENCES: ADHD brains show dysregulation in key neurotransmitter systems: Dopamine: Lower baseline levels affect motivation, reward processing, and attention Norepinephrine: Reduced availability impacts alertness and arousal regulation EXECUTIVE FUNCTION DEFICITS: The prefrontal cortex in ADHD brains shows reduced activity during tasks requiring: Response inhibition (stopping automatic responses) Working memory holding and manipulating information) Cognitive flexibility (switching between tasks) Sustained attention (maintaining focus over time) THE BOTTOM LINE: ADHD is a neurodevelopmental condition with clear biological markers

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