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Proton pump inhibitors (PPI) are the first-line treatment for peptic ulcers

We will still be adequately powered to make comparisons between these scenarios, and by shifting to 2 scenarios while retaining our total target enrollment, we will have higher numbers of individuals in these groups than planned which could allow us to evaluate additional moderating factors by subgroups, such as sex or age

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Combination therapies: Using multiple approaches may allow for lower doses of systemic medications