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1 2 3 4 Savarino et al
A Brief History of Smoking Tobacco has been grown and cultivated for hundreds of years
doi: 10.1002/ardp.201300238
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In light of this, the riskbenefit assessment in smokers suggests the use of a lower starting dose than in non-smokers (25 mg instead of 50 mg), with a further dose increase if clinical efficacy is not achieved [66]
