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Smoking is one of the primary risk factors for heart disease and the single most preventable cause of cardiovascular conditions

It is a mixture of the smoke from the burning end of the cigarette (or other smoked tobacco product) and the smoke breathed out by smokers

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It's impossible to know for sure how much of link is "causal" without doing a trial, which would be difficult for this topic
It is likely unsurprising that Big Tobacco is attaching great significance to receiving the first FDA clearance to market e-cigarette products in the United States
