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For cars with light or occasional smoke exposure (a few cigarettes over months), a thorough interior detailing session that includes a steam clean and enzyme-based odor treatment is usually enough to eliminate the cigarette smell completely

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However, in case of APAP overdose, the available pool of GSH becomes limited in the liver, resulting in binding of unconjugated NAPQI to cellular proteins (Mitchell et al., 1973), leading to mitochondrial dysfunction and hepatocellular necrosis (Larsen and Wendon, 2014)