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Remember how nicotines activation of nicotinic acetylcholine receptors can stimulate the vagus nerve, which plays a central role in regulating the cholinergic anti-inflammatory pathway

Circulation, 107 (3), 499511

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In neurons and mouse Parkinsons models, nicotine reduced SIRT6, a ritalin linked to heightened TNF- signaling and neuroinflammation, and this reduction contributed to neuroprotection

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