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Arthur Holmes developed his substratum convection hypothesis, (1929), but not until the 1940s did he refer to it as the mantle ( A Review oif the Continental Drift Hypothesis

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With regard to the physiology of the hypothalamic-pituitary-gonadal (HPG) axis, when FSH and LH levels increase, a resulting elevation of testosterone and inhibin B is anticipated, which in turn decreases FSH and LH levels by negative feedback

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