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Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes

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When nicotine is taken regularly, the brain builds up a tolerance to the levels of dopamine being produced, eventually becoming unable to produce the same levels on its own

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Caballeria L, Pera G, Auladell MA, Toran P, Munoz L, Miranda D, et al