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Smoking changes the way methylation works, which means it can also change gene activity

However, additional additives and adsorbents (such as carbon) may be added to optimise filtration of certain constituents, through either providing a mechanical influence on the smoke stream flow, or through interacting chemically with the smoke stream constituents

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For example, one meta analysis of 12 NRT trials found 30% of people who quit using nicotine replacement therapies relapsed within a year

Gouae et al

J., & Kollins, S