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The pharmacokinetics of injectable weight loss medications remain largely unchanged after gallbladder removal

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But even if money were not an issue, Hill says, there are a number of other factors that could lead patients to decide not to take GLP-1s long-term (see below)

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Some users lose more, many lose less, and a significant portion report no meaningful weight loss

Delay in Gastric Emptying : By mimicking the effects of GLP-1, Wegovy delays gastric emptying, meaning it slows down the rate at which food leaves the stomach and enters the small intestine