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GLP-1MK-801 also displayed superior weight loss efficacy compared with co-administration of GLP-1 and MK-801, despite having similar effects on food intake (Extended Data Fig

Remember that GLP-1s work best as part of a complete plan that includes healthy eating and regular activity

They commonly ignore reasons a doctor might adjust doses such as why increase Zepbound dose for metabolic results

Sterne JAC, Savovi J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials

GLP1: the early steps of a success story

However, the enzyme DPP-4 rapidly degrades circulating GLP-1, limiting its duration of action
