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SARS-CoV-2 infection abates the ACE2 receptor, which increases the cellular concentration of angiotensin resulting in an elevated level of oxidants, oxidative stress, and inflammation [126,127,128]

Sirtuins are NAD+-dependent enzymes that regulate gene expression, DNA repair, and cellular metabolismessentially serving as master regulators of cellular health and longevity

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This nanoparticle successfully penetrated intestinal barriers, enabling efficient insulin delivery and a significant reduction in blood glucose levels in diabetic rats [82]
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