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Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the National Comorbidity Survey

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These exposures may induce adaptive epigenetic responses in the fetus, such as changes in gene expression, DNA methylation patterns and chromatin structure, which enable survival under suboptimal conditions but may lead to long-term alterations in organ development, metabolic regulation and neuroendocrine function

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There is increasing evidence that mutated p53 enhances tumor metastasis and affects EMT processes [139]
