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[10] In "One Son", Jeffrey finds out that his father, the Smoking Man, forced his mother Cassandra to undergo medical treatments that led to several nervous breakdowns during his childhood years

A persons brain does not fully develop until the age of 25

It has been known for a long time that people who undergo chemotherapy to treat their cancer have a poor survival rate if they continue to smoke during the treatment
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Upon UVR-induced DNA damage, different pathways lead to the dissociation of the p53/mouse double minute 2 (MDM2) inhibitory complex [28] and two major kinases, ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR), mediate p53 phosphorylation, preventing its degradation [29]

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