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Presence of chronically increased number of leukocytes in smokers contributes in pathogenesis of smoking related diseases, especially ischaemic vascular disease, considering that increase in aggregation of leukocytes predisposes microcirculatory occlusion and vascular damage

Solar radiation, especially UV, is known to induce the activation of the MAPK pathways 5,29 , which in turn can upregulate the MMP expression 30,31 and alter the TGF-/Smads pathway 29

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