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Intracranial self-stimulation (ICSS) can also serve as an assessment of anhedonia or aversive state, in which rodents in an aversive state have been found to press a lever or spin a wheel to obtain higher levels of brain electrical self-stimulation (77, 78)

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Citing a review of biomarker studies in 2018 by Public Health England, Bates said, Vaping poses only a small fraction of the risks of smoking and switching completely from smoking to vaping conveys substantial health benefits over continued smoking. Bates also noted that there is no credible evidence to support a gateway effect or the existence of vapor or heated tobacco products causes smoking in adolescents that would not otherwise happen