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It has been widely used in these countries for over 500 years
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"A number of techniques can be used to successfully reduce specific chemical compounds, or alkaloids, in plants such as tobacco, but research has shown that some of these techniques can increase other harmful chemical compounds while reducing the target compound, said De-Yu Xie, professor of plant and microbial biology at NC State and the corresponding author of a paper describing the research
doi:10.1016/S1368-8375(98)00047-5
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Long-term cannabis use is associated with increased risk of stroke, heart attacks and irregular heartbeats
