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The analysis found that people taking GLP-1 or GLP-1/GIP drugs were diagnosed with SIBO about twice as often as those taking other diabetes medications

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The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation

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