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34,37 The requirement for local metabolic activation of NNK in the mouse lung has been elegantly demonstrated by experiments using mice in which cytochrome P450-reductase, the requisite co-factor for cytochrome P450-catalyzed metabolic activation of NNK, has been knocked out in the lung, 38 and a polymorphism in Cyp 2A5 decreased NNK-induced DNA adduct formation and lung tumorigenesis, as seen in parallel epidemiologic studies of lung cancer

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Among these compounds include pesticides, asbestos, particulate matter (PM), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons, heavy metals and physical (ionizing and non-ionizing radiations such as exposure to radon or ultraviolet (UV) radiation, respectively) [10,38]

I picture them as toddlers running around in our yard." Notaro also can't wait for their kids to make it into her comedy

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