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Change in habit over several decades in favor of filters led to a switch in pathology, Brawley said

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But other than its addictive properties (which incidentally appear reduced when separated out from other chemicals resident in the smoke) nicotine is a relatively benign drug

However, as discussed below, this finding is most plausibly explained by healthy switcher bias, residual confounding by age, body mass index, and other unmeasured factors, and the variable and uncontrollable effects of prior tobacco exposure in the vaping group, rather than by any protective effect of e-cigarette use

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